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Importantly, these receptors were observed to are already activated by a variety of endogenous opioids at a concentration just like that noticed for activation and signaling of classical opiate receptors. Consequently, these receptors have been discovered to possess scavenging action, binding to and reducing endogenous levels of opiates available f

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Researchers have not too long ago recognized and succeeded in synthesizing conolidine, a pure compound that demonstrates guarantee as a powerful analgesic agent with a far more favorable safety profile. Although the correct system of motion stays elusive, it can be at the moment postulated that conolidine may have quite a few biologic targets. Pres

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